LymphedemaV1, Main, Exploration, bibRecord, 00D013

Treatment of lymphedema of the arms and legs with 5,6-benzo-[α]-pyrone

Identifieur interne : 00D013 ( Main/Exploration ); précédent : 00D012; suivant : 00D014

Treatment of lymphedema of the arms and legs with 5,6-benzo-[α]-pyrone

Auteurs : J. R. Casley-Smith [Australie] ; R. G. Morgan ; N. B. Piller

Source :

The New England journal of medicine [ 0028-4793 ] ; 1993.

RBID : Pascal:94-0003914

Descripteurs français

KwdFr :
- Adulte d'âge moyen, Bras (anatomopathologie), Coumarines (effets indésirables), Coumarines (usage thérapeutique), Femelle, Humains, Jambe (anatomopathologie), Lymphoedème (anatomopathologie), Lymphoedème (physiopathologie), Lymphoedème (traitement médicamenteux), Maladie chronique, Mâle, Méthode en double aveugle, Température cutanée, Études de suivi.
MESH :
- anatomopathologie : Bras, Jambe, Lymphoedème.
- effets indésirables : Coumarines.
- physiopathologie : Lymphoedème.
- traitement médicamenteux : Lymphoedème.
- usage thérapeutique : Coumarines.
Pascal (Inist)
- Adulte d'âge moyen, Femelle, Humains, Lymphatique pathologie, Maladie chronique, Membre inférieur, Membre supérieur, Mâle, Méthode en double aveugle, Résultat, Température cutanée, Traitement, Homme, Chimiothérapie, Antiinflammatoire, Chirurgie, Lymphoedème, Etude longitudinale, 5,6-Benzo-(α)-pyrone, Études de suivi.
Wicri :
- topic : Homme, Chirurgie.

English descriptors

KwdEn :
- Antiinflammatory agent, Arm (pathology), Chemotherapy, Chronic Disease, Coumarins (adverse effects), Coumarins (therapeutic use), Double-Blind Method, Female, Follow up study, Follow-Up Studies, Human, Humans, Leg (pathology), Lower limb, Lymphatic vessel disease, Lymphedema, Lymphedema (drug therapy), Lymphedema (pathology), Lymphedema (physiopathology), Male, Middle Aged, Result, Skin Temperature, Surgery, Treatment, Upper limb.
MESH :
- chemical , adverse effects : Coumarins.
- drug therapy : Lymphedema.
- pathology : Arm, Leg, Lymphedema.
- physiopathology : Lymphedema.
- chemical , therapeutic use : Coumarins.
- Chronic Disease, Double-Blind Method, Female, Follow-Up Studies, Humans, Male, Middle Aged, Skin Temperature.

Abstract

Background. Benzopyrones can reduce the volume of high-protein edema fluid by stimulating proteolysis. These compounds provide a method for removing excess protein and its consequent edema and reduce its clinical sequelae, such as chronic inflammation and secondary infections. Methods. We conducted a randomized, double-blind, placebo-controlled, crossover trial of 5,6-benzo-[α]-pyrone in 31 patients with postmastectomy lymphedema of the arm and 21 patients with lymphedema of the leg of various causes. This agent is also known as 56 BaP, 1,2-benzopyrone, and coumarin, although it has no anticoagulant activity. The patients received 400 mg of the active drug or placebo, each for six months. Results. During the placebo period, lymphedema often worsened, especially in the arms

Affiliations:

Australie

Le document en format XML

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<term>Coumarins (therapeutic use)</term>
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<term>Lymphedema (physiopathology)</term>
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<term>Middle Aged</term>
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<term>Skin Temperature</term>
<term>Surgery</term>
<term>Treatment</term>
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<term>Skin Temperature</term>
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<term>Femelle</term>
<term>Humains</term>
<term>Lymphatique pathologie</term>
<term>Maladie chronique</term>
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<front><div type="abstract" xml:lang="en">Background. Benzopyrones can reduce the volume of high-protein edema fluid by stimulating proteolysis. These compounds provide a method for removing excess protein and its consequent edema and reduce its clinical sequelae, such as chronic inflammation and secondary infections. Methods. We conducted a randomized, double-blind, placebo-controlled, crossover trial of 5,6-benzo-[α]-pyrone in 31 patients with postmastectomy lymphedema of the arm and 21 patients with lymphedema of the leg of various causes. This agent is also known as 56 BaP, 1,2-benzopyrone, and coumarin, although it has no anticoagulant activity. The patients received 400 mg of the active drug or placebo, each for six months. Results. During the placebo period, lymphedema often worsened, especially in the arms</div>
</front>
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<country name="Australie"><noRegion><name sortKey="Casley Smith, J R" sort="Casley Smith, J R" uniqKey="Casley Smith J" first="J. R." last="Casley-Smith">J. R. Casley-Smith</name>
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Treatment of lymphedema of the arms and legs with 5,6-benzo-[α]-pyrone

Treatment of lymphedema of the arms and legs with 5,6-benzo-[α]-pyrone

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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